Hassel Jessica C, Meier Ramon, Joller-Jemelka Helen, Burg Günter, Dummer Reinhard
Department of Dermatology, University of Zürich Medical School, Zurich, Switzerland.
Dermatology. 2004;209(4):296-300. doi: 10.1159/000080852.
As serological immunomarkers like neopterin, beta2-microglobulin, soluble IL-2 receptor (sIL-2R) and IL-6 have been described to be elevated in various malignancies, the aim of this study was to investigate whether they would be of diagnostic and prognostic value for leukemic and non-leukemic cutaneous T cell lymphoma (CTCL).
Forty-one CTCL patients from the lymphoma clinics of the Department of Dermatology, University of Zurich, were tested for the serum levels of the above-mentioned immunomarkers at several time points, and clinical status and clinical outcome were recorded. Thirty-nine patients with CBCL and T cell inflammatory diseases served as controls.
The study revealed that neopterin, beta2-MG and sIL-2R are significantly elevated in Sezary syndrome, whereby sIL-2R seemed to be the most sensitive marker and is typically increased in Sezary syndrome. Moreover, there is a correlation between tumor burden index values and serum parameters. Concerning the outcome of the disease (progression versus non-progression), only neopterin showed a significant prognostic value in non-leukemic CTCL patients.
Serological immunomarkers are helpful tools in determining the tumor burden in CTCL and thus might be useful for disease monitoring during treatment. They may have prognostic value for predicting the clinical course.
由于已报道新蝶呤、β2-微球蛋白、可溶性白细胞介素-2受体（sIL-2R）和白细胞介素-6等血清学免疫标志物在各种恶性肿瘤中升高，本研究旨在调查它们对白血病性和非白血病性皮肤T细胞淋巴瘤（CTCL）是否具有诊断和预后价值。
对来自苏黎世大学皮肤科淋巴瘤门诊的41例CTCL患者在多个时间点检测上述免疫标志物的血清水平，并记录临床状态和临床结局。39例皮肤B细胞淋巴瘤（CBCL）患者和T细胞炎性疾病患者作为对照。
研究显示，新蝶呤、β2-微球蛋白和sIL-2R在Sezary综合征中显著升高，其中sIL-2R似乎是最敏感的标志物，在Sezary综合征中通常升高。此外，肿瘤负荷指数值与血清参数之间存在相关性。关于疾病结局（进展与未进展），仅新蝶呤在非白血病性CTCL患者中显示出显著的预后价值。
血清学免疫标志物是确定CTCL肿瘤负荷的有用工具，因此可能有助于治疗期间的疾病监测。它们可能对预测临床病程具有预后价值。
