Löbner K, Füchtenbusch M
Institut für Diabetesforschung und Med. Klinik 3, Lehrkrankenhaus München-Schwabing.
MMW Fortschr Med. 2004 Sep 2;146(35-36):32-3, 35-6.
The focus of current diabetes research is the clarification of the pathogenetic relationships between subclinical inflammation, diabetes and arteriosclerosis. Even minimal disturbances in glucose tolerance are associated with a chronic, generalized inflammatory reaction that links components of the metabolic syndrome and contributes to the development of diabetic complications as well as to the development and progression of arteriosclerosis. The most important mediators and markers of this inflammation cascade are NF-kappaB, TNF-alpha, IL-6, CRP and PAI-1. For the treatment of subclinical inflammation, substances with anti-inflammatory properties such as statins or ACE inhibitors are of increasing importance.
当前糖尿病研究的重点是阐明亚临床炎症、糖尿病和动脉硬化之间的发病机制关系。即使是糖耐量的微小紊乱也与一种慢性全身性炎症反应相关，这种炎症反应将代谢综合征的各个组成部分联系起来，并促成糖尿病并发症的发展以及动脉硬化的发生和进展。这种炎症级联反应最重要的介质和标志物是核因子κB、肿瘤坏死因子-α、白细胞介素-6、C反应蛋白和纤溶酶原激活物抑制剂-1。对于亚临床炎症的治疗，具有抗炎特性的物质如他汀类药物或血管紧张素转换酶抑制剂的重要性日益增加。
