Cong Xiu Li, Han Zhong Chao
State Key Laboratory of Experimental Hematology, Institute of Hematology and Hospital of Blood Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin, China.
Int J Hematol. 2004 Oct;80(3):232-8. doi: 10.1532/ijh97.a10408.
Survivin is a unique member of the inhibitor-of-apoptosis family. Survivin plays a role in the proliferation and survival of normal hematopoietic cells. Survivin expression is aberrantly enhanced in most cancers and hematopoietic malignancies. Survivin is an attractive therapeutic target, and various approaches to targeting survivin have been tested in vitro and in vivo. We review here progress in survivin research.
生存素是凋亡抑制蛋白家族的一个独特成员。生存素在正常造血细胞的增殖和存活中发挥作用。在大多数癌症和造血系统恶性肿瘤中，生存素的表达异常增强。生存素是一个有吸引力的治疗靶点，针对生存素的各种方法已在体外和体内进行了测试。我们在此综述生存素研究的进展。
