Sabel Michael S, Nehs Matthew A
Department of Surgery, University of Michigan, 3304 Cancer Center, 1500 East Medical Center Drive, Ann Arbor, MI 48109, USA.
Surg Oncol Clin N Am. 2005 Jan;14(1):1-31, v. doi: 10.1016/j.soc.2004.07.003.
The need for less toxic adjuvant therapies and a better understanding of the processes by which the immune system can eradicate micrometastatic disease has generated significant interest in breast cancer immunotherapy. There are many potential approaches to stimulating an immune response against a tumor, each with relative advantages and disadvantages in regards to cost, immunogenicity, and clinical applicability in treating breast cancer. This article will review the mechanisms by which the immune system can recognize and eradicate neoplastic cells and the various methods of stimulating an anti-tumor immune response. Obstacles to the clinical effectiveness of immunotherapies in breast cancer are also discussed.
对毒性较小的辅助治疗的需求以及对免疫系统根除微转移疾病过程的更好理解，引发了人们对乳腺癌免疫治疗的浓厚兴趣。刺激针对肿瘤的免疫反应有许多潜在方法，每种方法在成本、免疫原性以及治疗乳腺癌的临床适用性方面都有相对的优缺点。本文将综述免疫系统识别和根除肿瘤细胞的机制以及刺激抗肿瘤免疫反应的各种方法。还将讨论免疫疗法在乳腺癌临床疗效方面的障碍。
