咖啡因对大鼠帕金森病模型神经退行性变的保护作用：行为学和组织化学证据。
Protective effect of caffeine against neurodegeneration in a model of Parkinson's disease in rat: behavioral and histochemical evidence.
作者信息
Joghataie Mohammad Taghi, Roghani Mehrdad, Negahdar Fereidoun, Hashemi Leila
机构信息
Department of Anatomy, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.
出版信息
Parkinsonism Relat Disord. 2004 Dec;10(8):465-8. doi: 10.1016/j.parkreldis.2004.06.004.
Epidemiological studies have consistently demonstrated an inverse association between coffee consumption and Parkinson's disease (PD). This study was designed to investigate the beneficial effect of caffeine at a dose comparable to that of human exposure in a model of PD. For this purpose, unilateral intrastriatal 6-hydroxydopamine (6-OHDA)-lesioned rats were pretreated with caffeine (20 mg/kg; i.p.) 1 h before surgery and treated twice a day (10 mg/kg) for 1 month. Apomorphine-induced rotations and number of Nissl-stained neurons of substantia nigra pars compacta (SNC) were counted. The results demonstrated that caffeine administration for 1 month could attenuate the rotational behavior in lesioned rats and protect the neurons of SNC against 6-OHDA toxicity.
流行病学研究一直表明，咖啡消费与帕金森病（PD）之间存在负相关。本研究旨在探讨在帕金森病模型中，与人体接触剂量相当的咖啡因剂量的有益作用。为此，对单侧纹状体内注射6-羟基多巴胺（6-OHDA）损伤的大鼠在手术前1小时用咖啡因（20mg/kg；腹腔注射）进行预处理，并每天治疗两次（10mg/kg），持续1个月。计算阿扑吗啡诱导的旋转次数和黑质致密部（SNC）尼氏染色神经元的数量。结果表明，给予咖啡因1个月可减轻损伤大鼠的旋转行为，并保护SNC神经元免受6-OHDA毒性的影响。
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