The Cellular and Molecular Pharmacology Department, The Chicago Medical School, Rosalind Franklin University of Medicine and Science North Chicago, IL, USA.
The Nutrition Department, The College of Health Professions, Rosalind Franklin University of Medicine and Science North Chicago, IL, USA.
Front Aging Neurosci. 2014 Mar 7;6:36. doi: 10.3389/fnagi.2014.00036. eCollection 2014.
Parkinson's disease (PD) is the second most prevalent neurodegenerative disease in ageing individuals. It is now clear that genetic susceptibility and environmental factors play a role in disease etiology and progression. Because environmental factors are involved with the majority of the cases of PD, it is important to understand the role nutrition plays in both neuroprotection and neurodegeneration. Recent epidemiological studies have revealed the promise of some nutrients in reducing the risk of PD. In contrast, other nutrients may be involved with the etiology of neurodegeneration or exacerbate disease progression. This review summarizes the studies that have addressed these issues and describes in detail the nutrients and their putative mechanisms of action in PD.
帕金森病（PD）是老年人中第二常见的神经退行性疾病。现在很清楚，遗传易感性和环境因素在疾病的病因和进展中起作用。由于环境因素与大多数 PD 病例有关，因此了解营养在神经保护和神经退行性变中的作用非常重要。最近的流行病学研究表明，某些营养素具有降低 PD 风险的潜力。相比之下，其他营养素可能与神经退行性变的病因有关，或者加剧疾病的进展。这篇综述总结了研究这些问题的研究，并详细描述了营养素及其在 PD 中的潜在作用机制。
