巴西长期护理机构中接种疫苗的居民对肺炎球菌荚膜多糖抗体反应的持续性。

Persistence of antibody response to pneumococcal capsular polysaccharides in vaccinated long term-care residents in Brazil.

作者信息

Brandão Angela Pires, de Oliveira Tânia Cristina, de Cunto Brandileone Maria Cristina, Gonçalves Jorge Emílio, Yara Teresa Ikuko, Simonsen Vera

机构信息

Fundação Oswaldo Cruz, Rio de Janeiro, RJ 21045-900, Brazil.

出版信息

Vaccine. 2004 Dec 21;23(6):762-8. doi: 10.1016/j.vaccine.2004.07.024.

DOI:10.1016/j.vaccine.2004.07.024

PMID:15542200

Abstract

To evaluate the immunogenicity of 23-valent pneumococcal polysaccharide vaccine in 52 nursing homes residents aged > or = 60 years, IgG antibodies to serotypes 1, 5, 6B, and 8 were measured by ELISA and compared before, and 1 and 12 months following vaccination. A significant immunological response for all serotypes was observed at 1 month after vaccination. The mean increase in antibody concentration was highly variable and ranged from 1.6 to 2.7. After 1 year, the mean concentrations remained significantly higher than prior to vaccination for serotypes 1, 6B, and 8, although there was a decrease in all mean IgG concentrations. Antibody levels were higher in men than in women, before and after immunisation. Post-vaccination values tended to be lower among subjects aged >75 years. Reduction in IgG concentrations by 33% 1 year after vaccination suggests that revaccination of institutionalised elderly people may be needed.

摘要

为评估23价肺炎球菌多糖疫苗在52名年龄≥60岁的养老院居民中的免疫原性，通过酶联免疫吸附测定法（ELISA）测定了针对血清型1、5、6B和8的IgG抗体，并在接种疫苗前、接种后1个月和12个月进行了比较。接种疫苗后1个月观察到所有血清型均有显著的免疫反应。抗体浓度的平均增幅变化很大，范围为1.6至2.7。1年后，血清型1、6B和8的平均浓度仍显著高于接种疫苗前，尽管所有平均IgG浓度均有所下降。免疫前后，男性的抗体水平均高于女性。接种疫苗后，75岁以上受试者的值往往较低。接种疫苗1年后IgG浓度降低33%表明可能需要对机构养老的老年人进行再次接种。