Gridley Thomas
The Jackson Laboratory, Bar Harbor, Maine 04609, USA.
Cancer Cell. 2004 Nov;6(5):431-2. doi: 10.1016/j.ccr.2004.10.019.
While the human NOTCH1 gene initially was cloned as part of a translocation breakpoint in T cell acute lymphoblastic leukemia (T-ALL) tumors, this translocation is present in only a small percentage of T-ALL patients. A recent paper by Weng et al. (2004) demonstrates that novel types of activating mutations in the NOTCH1 gene occur in more than half of all T-ALL cases, implicating NOTCH1 as a major player in the etiology of T-ALL.
虽然人类NOTCH1基因最初是作为T细胞急性淋巴细胞白血病（T-ALL）肿瘤中一个易位断点的一部分被克隆出来的，但这种易位仅存在于一小部分T-ALL患者中。翁等人（2004年）最近发表的一篇论文表明，NOTCH1基因的新型激活突变发生在超过一半的T-ALL病例中，这表明NOTCH1是T-ALL病因中的一个主要因素。
