Perez-Parada Jorge, Saffran Holly A, Smiley James R
Department of Medical Microbiology & Immunology, 632 Heritage Medical Research Centre, University of Alberta, Edmonton, Alberta, Canada.
J Virol. 2004 Dec;78(23):13391-4. doi: 10.1128/JVI.78.23.13391-13394.2004.
The herpes simplex virus virion host shutoff protein (vhs) is an mRNA-specific RNase that contributes to shutoff of host protein synthesis. We show here that vhs-induced mRNA decay proceeds 5' to 3' in an in vitro assay system derived from rabbit reticulocyte lysate.
单纯疱疹病毒病毒体宿主关闭蛋白(vhs)是一种mRNA特异性核糖核酸酶,有助于宿主蛋白质合成的关闭。我们在此表明,在源自兔网织红细胞裂解物的体外测定系统中,vhs诱导的mRNA衰变从5'到3'进行。