Anton E S, Ghashghaei H T, Weber Janet L, McCann Corey, Fischer Tobias M, Cheung Isla D, Gassmann Martin, Messing Albee, Klein Rudiger, Schwab Markus H, Lloyd K C Kent, Lai Cary
UNC Neuroscience Center and the Department of Cell and Molecular Physiology, The University of North Carolina School of Medicine, Chapel Hill, North Carolina 27599, USA.
Nat Neurosci. 2004 Dec;7(12):1319-28. doi: 10.1038/nn1345. Epub 2004 Nov 7.
Neural progenitor proliferation, differentiation and migration are continually active in the rostral migratory stream of the adult brain. Here, we show that the receptor tyrosine kinase ErbB4 is expressed prominently by the neuroblasts present in the subventricular zone and the rostral migratory stream. The neuregulins (NRG1-NRG3), which have been identified as ErbB4 ligands, are detected either in the stream or in adjacent regions. Mice deficient in ErbB4 expressed under the control of either the nestin or the hGFAP promoter have altered neuroblast chain organization and migration and deficits in the placement and differentiation of olfactory interneurons. These findings suggest that ErbB4 activation helps to regulate the organization of neural chains that form the rostral migratory stream and influences the differentiation of olfactory interneuronal precursors.
神经祖细胞的增殖、分化和迁移在成人大脑的吻侧迁移流中持续活跃。在此，我们表明受体酪氨酸激酶ErbB4在脑室下区和吻侧迁移流中的神经母细胞中显著表达。已被鉴定为ErbB4配体的神经调节蛋白（NRG1-NRG3）在迁移流或相邻区域中被检测到。在巢蛋白或人胶质纤维酸性蛋白（hGFAP）启动子控制下缺乏ErbB4的小鼠，其神经母细胞链的组织和迁移发生改变，嗅觉中间神经元的定位和分化存在缺陷。这些发现表明，ErbB4的激活有助于调节形成吻侧迁移流的神经链的组织，并影响嗅觉中间神经元前体的分化。
