Virginia Tech Graduate Program in Translational Biology, Medicine and Health, Virginia Polytechnic Institute and State University, Roanoke, VA, USA; Department of Biological Sciences and Pathobiology, Virginia-Maryland College of Veterinary Medicine, Virginia Polytechnic Institute and State University, Blacksburg, VA, USA.
Department of Biological Sciences and Pathobiology, Virginia-Maryland College of Veterinary Medicine, Virginia Polytechnic Institute and State University, Blacksburg, VA, USA.
Stem Cell Reports. 2022 Sep 13;17(9):2097-2110. doi: 10.1016/j.stemcr.2022.07.015. Epub 2022 Aug 18.
In the past decade it has become evident that neuroblasts continue to supply the human cortex with interneurons via unique migratory streams shortly following birth. Owing to the size of the human brain, these newborn neurons must migrate long distances through complex cellular landscapes to reach their final locations. This process is poorly understood, largely because of technical difficulties in acquiring and studying neurotypical postmortem human samples along with diverging developmental features of well-studied mouse models. We reasoned that migratory streams of neuroblasts utilize cellular substrates, such as blood vessels, to guide their trek from the subventricular zone to distant cortical targets. Here, we evaluate the association between young interneuronal migratory streams and their preferred cellular substrates in gyrencephalic piglets during the developmental equivalent of human birth, infancy, and toddlerhood.
在过去的十年中，人们已经明显认识到，在出生后不久，神经前体细胞通过独特的迁移流继续为人类大脑皮层提供中间神经元。由于人脑的体积较大，这些新生神经元必须通过复杂的细胞景观进行长距离迁移，才能到达其最终位置。由于在获取和研究神经典型的尸检人类样本方面存在技术困难，以及在研究得很好的小鼠模型中存在发育特征的差异，因此该过程尚不清楚。我们推断，神经前体细胞的迁移流利用血管等细胞基质来引导其从侧脑室区迁移到遥远的皮质靶标。在这里，我们在类人猿小猪的出生、婴儿和幼儿期的发育阶段，评估了年轻的中间神经元迁移流与其首选细胞基质之间的关系。
