Nonomura K, Saito H, Haraguchi M, Akimoto K, Hashimoto K, Katsunuma T, Akasawa A, Ebisawa M, Nagakura T, Iikura Y
Department of Allergy, National Children's Hospital.
Arerugi. 1992 Jan;41(1):29-35.
We studied the protective effect of sustained-release theophylline granules on early or late response in exercise-induced asthma (EIA) in 16 patients ranging in age from 7 to 18 years. A standardized exercise test was examined 2 hours after administration of theophylline granules on one day and after no medication on another day. On both days, the lung functions and the serum theophylline and cortisol concentrations of the patients were examined before exercise and over a period of 8 hours after exercise. On days without medication, early response was seen in 16 patients and late response in 6. On days with medication, the theophylline granules inhibited early response in 13 of the 16 patients and late response in 5 of the 6 patients. This suggests that theophylline preparation is a useful drug for inhibiting the dual responses of EIA.
我们研究了缓释茶碱颗粒对16名年龄在7至18岁的运动诱发性哮喘（EIA）患者早期或晚期反应的保护作用。在一天服用茶碱颗粒2小时后以及另一天不服药后进行标准化运动试验。在这两天，均在运动前以及运动后8小时内检测患者的肺功能、血清茶碱和皮质醇浓度。在不服药的日子里，16名患者出现早期反应，6名患者出现晚期反应。在服药的日子里，茶碱颗粒抑制了16名患者中13名的早期反应以及6名患者中5名的晚期反应。这表明茶碱制剂是抑制EIA双重反应的有效药物。
