阿齐霉素的生物合成研究：萘甲酸片段的合成途径。
Biosynthetic studies on the azinomycins: the pathway to the naphthoate fragment.
作者信息
Corre Christophe, Landreau Cyrille A S, Shipman Michael, Lowden Philip A S
机构信息
School of Biological and Chemical Sciences, University of Exeter, UK.
出版信息
Chem Commun (Camb). 2004 Nov 21(22):2600-1. doi: 10.1039/b410592c. Epub 2004 Sep 30.
DOI:10.1039/b410592c
PMID:15543299
Abstract
Isotopically labelled intermediates in a proposed biosynthesis of the naphthoate fragment of azinomycin B have been made and successfully incorporated by the azinomycin producing organism.
摘要
放线菌素B萘甲酸酯片段生物合成过程中所提出的同位素标记中间体已被制备出来，并被放线菌素产生菌成功整合。
相似文献
1
Biosynthetic studies on the azinomycins: the pathway to the naphthoate fragment.阿齐霉素的生物合成研究：萘甲酸片段的合成途径。
Chem Commun (Camb). 2004 Nov 21(22):2600-1. doi: 10.1039/b410592c. Epub 2004 Sep 30.
2
Biosynthesis of 3-methoxy-5-methyl naphthoic acid and its incorporation into the antitumor antibiotic azinomycin B.3-甲氧基-5-甲基萘甲酸的生物合成及其掺入抗肿瘤抗生素阿齐霉素B的过程。
Mol Biosyst. 2010 Jun;6(6):1071-81. doi: 10.1039/b926358f. Epub 2010 Mar 16.
3
Characterization of the azinomycin B biosynthetic gene cluster revealing a different iterative type I polyketide synthase for naphthoate biosynthesis.氮杂霉素B生物合成基因簇的特征分析揭示了一种用于萘甲酸生物合成的不同迭代型I聚酮合酶。
Chem Biol. 2008 Jul 21;15(7):693-705. doi: 10.1016/j.chembiol.2008.05.021.
4
Azinomycins A and B, new antitumor antibiotics. I. Producing organism, fermentation, isolation, and characterization.阿齐霉素A和B，新型抗肿瘤抗生素。I. 产生菌、发酵、分离及特性
J Antibiot (Tokyo). 1986 Nov;39(11):1527-32. doi: 10.7164/antibiotics.39.1527.
5
Exploration of the molecular origin of the azinomycin epoxide: timing of the biosynthesis revealed.氮霉素环氧化物的分子起源探索：揭示生物合成的时机
Org Lett. 2008 Nov 6;10(21):4815-8. doi: 10.1021/ol8018852. Epub 2008 Oct 9.
6
Genetic manipulation of antibiotic-producing Streptomyces.产抗生素链霉菌的基因操作
Trends Microbiol. 1998 Feb;6(2):76-83. doi: 10.1016/S0966-842X(97)01161-X.
7
In vitro biosynthesis of the antitumor agent azinomycin B.抗肿瘤药物氮霉素B的体外生物合成
Org Lett. 2006 Mar 16;8(6):1065-8. doi: 10.1021/ol052987l.
8
Aminoacetone as the penultimate precursor to the antitumor agent azinomycin A.
Org Lett. 2009 Sep 3;11(17):4006-9. doi: 10.1021/ol9016639.
9
Probing the Role of N-Acetyl-glutamyl 5-Phosphate, an Acyl Phosphate, in the Construction of the Azabicycle Moiety of the Azinomycins.探究酰基磷酸酯N-乙酰谷氨酰5-磷酸在氮霉素氮杂双环部分构建中的作用。
Biochemistry. 2015 Jul 28;54(29):4415-8. doi: 10.1021/acs.biochem.5b00711. Epub 2015 Jul 14.
10
Characterization of AziR, a resistance protein of the DNA cross-linking agent azinomycin B.氮霉素B抗性蛋白AziR的特性分析
Mol Biosyst. 2011 Sep;7(9):2563-70. doi: 10.1039/c1mb05136a. Epub 2011 Jul 21.
Zotero 插件