由三价钛茂催化的前所未有的巴比耶型反应。

Unprecedented Barbier-type reactions catalysed by titanocene(III).

作者信息

Rosales Antonio, Oller-López Juan L, Justicia José, Gansäuer Andreas, Oltra J Enrique, Cuerva Juan M

机构信息

Department of Organic Chemistry, Faculty of Sciences, University of Granada, Spain.

出版信息

Chem Commun (Camb). 2004 Nov 21(22):2628-9. doi: 10.1039/b411173g. Epub 2004 Oct 5.

DOI:10.1039/b411173g

PMID:15543313

Abstract

Selective Barbier-type allylations, benzylations and propargylations of aldehydes and ketones can be carried out under extremely mild conditions employing titanocene(III) complexes as catalysts. In this way, chiral titanocene catalysts provided yields ranging from 50-80% of optically active products.

摘要

使用二茂钛（III）配合物作为催化剂，醛和酮的选择性巴比耶型烯丙基化、苄基化和炔丙基化反应可在极其温和的条件下进行。通过这种方式，手性二茂钛催化剂得到的光学活性产物产率在50%至80%之间。