高区域选择性和化学选择性的二茂钛介导的巴比耶型烯丙基化反应。

Highly regioselective and chemoselective titanocene mediated Barbier-type allylation reactions.

作者信息

Morcillo Sara P, Martínez-Peragón Ángela, Jakoby Verena, Mota Antonio J, Kube Christian, Justicia José, Cuerva Juan M, Gansäuer Andreas

机构信息

Department of Organic Chemistry, University of Granada, Fuentenueva Campus, Granada 18071, Spain.

出版信息

Chem Commun (Camb). 2014 Feb 28;50(17):2211-3. doi: 10.1039/c3cc49230c. Epub 2014 Jan 16.

DOI:10.1039/c3cc49230c

PMID:24435404

Abstract

Titanocene carboxylate 1 is an excellent chemoselective reagent for unprecedented α-regioselective Barbier-type reactions. It constitutes the first titanocene(III) able to tolerate epoxides and readily reduced carbonyl compounds, such as aromatic and α,β-unsaturated aldehydes.

摘要

羧基二茂钛1是一种出色的化学选择性试剂，可用于前所未有的α-区域选择性巴比耶型反应。它是第一种能够耐受环氧化物以及易还原羰基化合物（如芳香醛和α,β-不饱和醛）的三价二茂钛。