三价钛促进的羰基化合物的巴比尔型烯丙基化反应。

Titanocene(III)-promoted Barbier-type crotylation of carbonyl compounds.

机构信息

Department of Organic Chemistry, Faculty of Sciences, University of Granada, C. U. Fuentenueva s/n, 18071 Granada, Spain.

出版信息

J Org Chem. 2011 Jan 21;76(2):732-5. doi: 10.1021/jo102269d. Epub 2010 Dec 29.

DOI:10.1021/jo102269d

PMID:21190366

Abstract

A mild, highly regio- and stereoselective method for the crotylation of aldehydes and ketones mediated/catalyzed by titanocene(III) is described. Optimized conditions permit the selective generation of γ-adducts in high yields together with high stereoselectivity, with a predominance of anti stereoisomers.

摘要

描述了由钛（III）介导/催化的醛和酮的高区域和立体选择性的温和克罗蒂化方法。优化条件允许以高产率和高立体选择性选择性地生成γ-加合物，反式异构体占优势。