Höijer U, Ejnell H, Hedner J, Petruson B, Eng L B
Department of Otorhinolaryngology, Sahlgrenska Hospital, University of Göteborg, Sweden.
Arch Otolaryngol Head Neck Surg. 1992 Mar;118(3):281-4. doi: 10.1001/archotol.1992.01880030069015.
The effects of nasal valve dilation on snoring and obstructed breathing were studied in 11 patients with habitual snoring and/or obstructive sleep apnea. The anterior part of the nose, the valve region, was dilated by means of a plastic device. Ten patients underwent polysomnographic investigation including pulse oximetry and measurement of snoring noise with and without the nasal dilator in a randomized manner. Snoring, nocturnal arousals, and daytime hypersomnolence were rated by the patient and partner on a questionnaire before and after a 10-day treatment period with the dilator. The nasal airflow, as assessed by rhinomanometry when awake in the sitting position, increased by 18% (range, 5.5% to 45%) when the nasal dilator was used. The frequency and severity of obstructed breathing decreased significantly with the nasal dilator. The apnea index with and without the nasal dilator was 6.4 (range, 1.3 to 15) and 18 (range, 1.8 to 60), respectively. The mean decrease of the apnea index was 47%. The overnight minimum arterial oxygen saturation (with and without the nasal dilator was 84% (range, 76% to 88%) and 78% (range, 68% to 89%), respectively. There was a substantial decrease in snoring noise (number of epochs with Leq values, equal energy level, above 55 or 60 dB) with the dilator in all patients who presented with snoring noise above these levels during the control night. No subjective effects on arousal frequency or daytime hypersomnolence were reported. Four of 11 patients were positive to continue using the nasal dilator.
对11名习惯性打鼾和/或阻塞性睡眠呼吸暂停患者研究了鼻瓣扩张对打鼾和阻塞性呼吸的影响。使用一种塑料装置扩张鼻前部即鼻瓣区。10名患者接受了多导睡眠图检查，包括脉搏血氧饱和度测定，并以随机方式在使用和不使用鼻扩张器的情况下测量打鼾噪音。在使用扩张器进行为期10天的治疗前后，患者及其伴侣通过问卷对打鼾、夜间觉醒和日间嗜睡情况进行评分。当使用鼻扩张器时，坐位清醒状态下通过鼻阻力计评估的鼻气流增加了18%（范围为5.5%至45%）。使用鼻扩张器后，阻塞性呼吸的频率和严重程度显著降低。使用和不使用鼻扩张器时的呼吸暂停指数分别为6.4（范围为1.3至15）和18（范围为1.8至60）。呼吸暂停指数的平均降低幅度为47%。夜间最低动脉血氧饱和度（使用和不使用鼻扩张器时）分别为84%（范围为76%至88%）和78%（范围为68%至89%）。在对照夜打鼾噪音水平高于上述水平的所有患者中，使用扩张器后打鼾噪音（Leq值即等效能量水平高于55或60 dB的时段数）大幅降低。未报告对觉醒频率或日间嗜睡有主观影响。11名患者中有4名愿意继续使用鼻扩张器。
