复发性呼吸道感染儿童中的L-纤维胶凝蛋白
L-ficolin in children with recurrent respiratory infections.
作者信息
Atkinson A P M, Cedzynski M, Szemraj J, St Swierzko A, Bak-Romaniszyn L, Banasik M, Zeman K, Matsushita M, Turner M L, Kilpatrick D C
机构信息
Scottish National Blood Transfusion Service, National Science Laboratory, Edinburgh, Scotland, UK.
出版信息
Clin Exp Immunol. 2004 Dec;138(3):517-20. doi: 10.1111/j.1365-2249.2004.02634.x.
Abstract
The lectin pathway of complement activation is used by a collectin, mannan-binding lectin (MBL), and two ficolins, L-ficolin and H-ficolin, to opsonize microorganisms for phagocytosis. We published evidence recently that MBL insufficiency is associated with recurrent respiratory infections in childhood. We have now measured serum L-ficolin in 313 respiratory infection patients and 74 healthy control children. L-ficolin concentrations below the lower limit of the control group were found in 6% of the patients (P <0.02) and were associated most strongly with children having co-existing atopic disorders (11%; P=0.002). We suggest that L-ficolin may have a role in protection from microorganisms complicating allergic disease.
摘要
补体激活的凝集素途径由一种凝集素、甘露聚糖结合凝集素（MBL）以及两种纤维胶凝蛋白（L-纤维胶凝蛋白和H-纤维胶凝蛋白）来利用，以调理微生物以便吞噬。我们最近发表的证据表明，MBL不足与儿童反复呼吸道感染有关。我们现在测量了313例呼吸道感染患者和74名健康对照儿童的血清L-纤维胶凝蛋白。6%的患者L-纤维胶凝蛋白浓度低于对照组下限（P<0.02），并且与患有并存特应性疾病的儿童关联最为密切（11%；P=0.002）。我们认为，L-纤维胶凝蛋白可能在预防使过敏性疾病复杂化的微生物方面发挥作用。
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L-ficolin specifically binds to lipoteichoic acid, a cell wall constituent of Gram-positive bacteria, and activates the lectin pathway of complement.L-纤维胶凝蛋白特异性结合脂磷壁酸（革兰氏阳性菌细胞壁的一种成分），并激活补体的凝集素途径。
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