Ramsey Jon J, Kemnitz Joseph W, Newton Wendy, Hagopian Kevork, Patterson Terrell A, Swick Andrew G
Department of Molecular Biosciences, School of Veterinary Medicine, University of California, Davis, CA 95616, USA.
Regul Pept. 2005 Jan 15;124(1-3):209-14. doi: 10.1016/j.regpep.2004.07.018.
Orexin A has been reported to stimulate food intake in rats while orexin B does not. The purpose of this study was to determine the role of orexin A or orexin B administration on food intake in adult, male rhesus monkeys. Food intake was measured at 2 and 8 h after the morning feeding following central injections of vehicle, orexin A (10, or 20 microg) or orexin B (10, 30, or 100 microg). When compared to vehicle injections, the 10 and 20 microg doses of orexin A decreased food intake at 2 h post-dose by 45% and 64%, respectively. Eight-hour food intake was decreased at only the 20 microg orexin A dose. Orexin B at all doses and time points did not alter food intake when compared to vehicle. These results indicate that orexin A exhibits anorectic activity while orexin B does not affect food intake in the rhesus monkey.
据报道，食欲素A可刺激大鼠的食物摄入量，而食欲素B则无此作用。本研究的目的是确定给予食欲素A或食欲素B对成年雄性恒河猴食物摄入量的影响。在晨间喂食后2小时和8小时，通过向中枢注射溶媒、食欲素A（10微克或20微克）或食欲素B（10微克、30微克或100微克）来测量食物摄入量。与注射溶媒相比，10微克和20微克剂量的食欲素A在给药后2小时分别使食物摄入量减少了45%和64%。仅20微克剂量的食欲素A使8小时食物摄入量减少。与溶媒相比，所有剂量和时间点的食欲素B均未改变食物摄入量。这些结果表明，食欲素A具有厌食活性，而食欲素B不影响恒河猴的食物摄入量。
