Grön Georg, Riepe Matthias W
Memory Clinic, Department of Neurology, University of Ulm, Steinhoevelstr. 1, 89075 Ulm, Germany.
Am J Geriatr Psychiatry. 2004 Nov-Dec;12(6):648-52. doi: 10.1176/appi.ajgp.12.6.648.
The authors hypothesize that, behaviorally, episodic memory in health and disease reflects a continuum.
Subjects (N=12) with very mild Alzheimer disease (AD) and normal subjects (N=24) were investigated with functional magnetic resonance imaging (fMRI) during an episodic memory task.
Recruitment of a posterior medio-temporal network was correlated with memory performance across the spectrum from high- and low-performing normal subjects to patients with early AD.
The behavioral spectrum from health to disease in episodic memory function is mirrored neurobiologically with graded recruitment of neuronal activation in medio-temporal regions. The results call for longitudinal assessment of behavioral decline and neuronal recruitment in future studies.
作者推测，在行为方面，健康及患病状态下的情景记忆反映出一种连续体。
对患有极轻度阿尔茨海默病（AD）的受试者（N = 12）和正常受试者（N = 24）在进行情景记忆任务期间采用功能磁共振成像（fMRI）进行研究。
从记忆表现良好和不佳的正常受试者到早期AD患者，整个范围内后颞中网络的激活均与记忆表现相关。
情景记忆功能从健康到疾病的行为谱在神经生物学上表现为颞中区域神经元激活的分级募集。研究结果呼吁在未来的研究中对行为衰退和神经元募集进行纵向评估。
