Keirns Bryant H, Keirns Natalie G, Sciarrillo Christina M, Medlin Austin R, Fruit Sarah E, Emerson Sam R
Department of Nutrition and Health Science, Ball State University, Muncie, 47306 IN, United States.
Department of Nutritional Sciences, Oklahoma State University, Stillwater, 74075 OK, United States.
J Nutr Health Aging. 2025 Mar;29(3):100468. doi: 10.1016/j.jnha.2024.100468. Epub 2025 Jan 8.
Postprandial inflammation post-high-fat meals may be linked to cardiovascular disease (CVD). CVD incidence increases with age; however, whether older adults experience greater postprandial inflammation remains unclear. We examined whether analyzing age categorically versus continuously influenced relationships between age and postprandial inflammatory measures.
Cross-sectional.
Laboratory for Applied Nutrition and Exercise Science at Oklahoma State University (Stillwater, OK, USA).
56 apparently healthy adults ages 20-69 years.
We measured interleukin (IL)-1β, IL-6, IL-8, IL-10, and tumor necrosis factor (TNF)-α at baseline, 2-, 4-, and 6 -hs post-high-fat meal (9 kcal/kg; 70% fat). Data were examined in the full sample with paired t-tests (baseline to peak), by pre-defined age groups (i.e., 18-35, 36-49, 50-59, 60-69) using ANCOVA, and continuously using linear regression.
Across the full sample, IL-1β, IL-6, and IL-8 increased after the high-fat meal (p's≤0.018). Cytokine differences post-high-fat meal by age category were generally not observed. However, age was positively associated with IL-6 incremental AUC when examined continuously (b = 0.029; p = 0.010).
These data suggest increasing age is linked to a greater IL-6 response to a high-fat meal. Further, examining age continuously may have greater utility when studying aging and postprandial inflammation.
N/A (secondary analysis).
高脂餐后的餐后炎症可能与心血管疾病（CVD）有关。CVD的发病率随年龄增长而增加；然而，老年人是否经历更严重的餐后炎症仍不清楚。我们研究了按年龄分类分析与连续分析对年龄与餐后炎症指标之间关系的影响。
横断面研究。
美国俄克拉荷马州立大学（斯蒂尔沃特）应用营养与运动科学实验室。
56名年龄在20 - 69岁之间的明显健康成年人。
我们在基线、高脂餐后2小时、4小时和6小时（9千卡/千克；70%脂肪）测量白细胞介素（IL）-1β、IL-6、IL-8、IL-10和肿瘤坏死因子（TNF）-α。数据在全样本中通过配对t检验（基线至峰值）进行检查，按预先定义的年龄组（即18 - 35岁、36 - 49岁、50 - 59岁、60 - 69岁）使用协方差分析，并通过线性回归进行连续分析。
在全样本中，高脂餐后IL-1β、IL-6和IL-8升高（p值≤0.018）。一般未观察到按年龄分类的高脂餐后细胞因子差异。然而，连续分析时年龄与IL-6增量AUC呈正相关（b = 0.029；p = 0.010）。
这些数据表明年龄增长与高脂餐后更大的IL-6反应有关。此外，在研究衰老与餐后炎症时，连续分析年龄可能更有用。
无（二次分析）。
