是什么决定了肾小球毛细血管的通透性？
What determines glomerular capillary permeability?
作者信息
Deen William M
机构信息
Department of Chemical Engineering, Division of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.
出版信息
J Clin Invest. 2004 Nov;114(10):1412-4. doi: 10.1172/JCI23577.
Abstract
There have been exciting recent advances in our understanding of the structural and molecular biology of the glomerular slit diaphragm, as described in a report in this issue of the JCI. These findings, combined with data on the permeability of the basement membrane and evidence that the endothelium may be a more important barrier than often supposed, are allowing a clearer understanding to emerge of how the 3 parts of the glomerular capillary wall jointly determine its functional properties.
摘要
正如本期《临床研究杂志》一篇报告中所述，我们对肾小球裂孔隔膜的结构和分子生物学的理解最近取得了令人兴奋的进展。这些发现，再加上关于基底膜通透性的数据以及有证据表明内皮可能是比通常认为的更为重要的屏障，使得我们能更清楚地了解肾小球毛细血管壁的三个部分如何共同决定其功能特性。
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