Arrigo André-Patrick
Laboratoire stress oxydant, chaperons et apoptose, Centre de Génétique Moléculaire et Cellulaire, CNRS UMR-5534, Université Claude Bernard Lyon-I, 69622 Villeurbanne, France.
J Cell Biochem. 2005 Feb 1;94(2):241-6. doi: 10.1002/jcb.20349.
Many differentiation programs are accompanied by an increase in small heat shock proteins (sHsps) level. Most of the time transient, this accumulation takes place during the early phase of the process and is correlated with the growth arrest that precedes the differentiation. Important biochemical modifications of sHsps occur, such as changes in phosphorylation and oligomerization. The fact that these proteins are induced independently of the signal that triggers differentiation, of the differentiation type, and of the cell type strongly suggests their involvement in fundamental mechanisms of cellular differentiation. Moreover, impairment of sHsps accumulation leads to abortion of the differentiation program and, subsequently, to a massive commitment to cell death. Recent advances in this field of research are presented as well as the hypothesis that should be tested to unravel the mode of action of these proteins during cellular differentiation.
许多分化程序伴随着小热休克蛋白（sHsps）水平的升高。大多数情况下这种积累是短暂的，发生在该过程的早期阶段，并且与分化之前的生长停滞相关。sHsps会发生重要的生化修饰，例如磷酸化和寡聚化的变化。这些蛋白质的诱导独立于触发分化的信号、分化类型和细胞类型，这一事实强烈表明它们参与了细胞分化的基本机制。此外，sHsps积累的受损会导致分化程序中止，随后导致大量细胞走向死亡。本文介绍了该研究领域的最新进展以及为阐明这些蛋白质在细胞分化过程中的作用方式而应进行检验的假说。
