Langrish Claire L, McKenzie Brent S, Wilson Nicholas J, de Waal Malefyt Rene, Kastelein Robert A, Cua Daniel J
Discovery Research, DNAX Research Inc., Palo Alto, CA 94304, USA.
Immunol Rev. 2004 Dec;202:96-105. doi: 10.1111/j.0105-2896.2004.00214.x.
Initiation of an effective immune response requires close interactions between innate and adaptive immunity. Recent advances in the field of cytokine biology have led to an increased understanding of how myeloid cell-derived factors regulate the immune system to protect the host from infections and prevent tumor development. In this review, we focus on the function of interleukin (IL)-23, a new member of the IL-12 family of regulatory cytokines produced by activated macrophages and dendritic cells. We propose that IL-12 and IL-23 promote two distinct immunological pathways that have separate but complementary functions. IL-12 is required for antimicrobial responses to intracellular pathogens, whereas IL-23 is likely to be important for the recruitment and activation of a range of inflammatory cells that is required for the induction of chronic inflammation and granuloma formation. These two cytokines work in concert to regulate cellular immune responses critical for host defense and tumor suppression.
有效的免疫反应的启动需要固有免疫和适应性免疫之间的密切相互作用。细胞因子生物学领域的最新进展使人们对髓样细胞衍生因子如何调节免疫系统以保护宿主免受感染和预防肿瘤发展有了更多的了解。在本综述中，我们重点关注白细胞介素（IL）-23的功能，它是由活化的巨噬细胞和树突状细胞产生的IL-12调节细胞因子家族的新成员。我们提出，IL-12和IL-23促进两种不同的免疫途径，它们具有各自独立但互补的功能。IL-12是针对细胞内病原体的抗菌反应所必需的，而IL-23可能对于诱导慢性炎症和肉芽肿形成所需的一系列炎症细胞的募集和激活很重要。这两种细胞因子协同作用，调节对宿主防御和肿瘤抑制至关重要的细胞免疫反应。
