Hölscher Christoph
Junior Research Group Molecular Infection Biology, Research Center Borstel, Parkallee 22, D-23845 Borstel, Germany.
Curr Opin Investig Drugs. 2005 May;6(5):489-95.
Dysregulated cell-mediated immune responses may lead to chronic inflammation and autoimmune disorders. The recent discovery of the dimeric interleukin (IL)-12-related cytokine IL-23 now adds to our understanding of the fine-tuning of cellular immunity. The critical implication of the role that IL-12p40 plays in autoimmune inflammation has long been misinterpreted and only recently have studies revealed that it is IL-23, and not IL-12, that is the decisive factor in this immune deviation. Therefore, targeting of IL-23 or the IL-23 receptor is a promising therapeutic approach for autoimmune diseases. This review summarizes recent findings regarding IL-23-mediated autoreactive inflammatory responses, and introduces possible therapeutic interventions that are aimed at mitigating autoimmune inflammation.
细胞介导的免疫反应失调可能导致慢性炎症和自身免疫性疾病。最近发现的二聚体白细胞介素（IL）-12相关细胞因子IL-23，加深了我们对细胞免疫微调的理解。长期以来，人们一直误解IL-12p40在自身免疫性炎症中所起作用的关键含义，直到最近的研究才表明，在这种免疫偏差中起决定性作用的是IL-23，而不是IL-12。因此，靶向IL-23或IL-23受体是治疗自身免疫性疾病的一种有前景的治疗方法。这篇综述总结了关于IL-23介导的自身反应性炎症反应的最新发现，并介绍了旨在减轻自身免疫性炎症的可能治疗干预措施。
