Hoitsma E, Reulen J P H, de Baets M, Drent M, Spaans F, Faber C G
Department of Clinical Neurophysiology, Maastricht University Hospital, Maastricht, The Netherlands.
J Neurol Sci. 2004 Dec 15;227(1):119-30. doi: 10.1016/j.jns.2004.08.012.
Small fiber neuropathy (SFN) is a neuropathy selectively involving small diameter myelinated and unmyelinated nerve fibers. Interest in this disorder has considerably increased during the past few years. It is often idiopathic and typically presents with peripheral pain and/or symptoms of autonomic dysfunction. Diagnosis is made on the basis of the clinical features, normal nerve conduction studies (NCS) and abnormal specialized tests of small nerve fibers. Among others, these tests include assessment of epidermal nerve fiber density, temperature sensation tests for sensory fibers and sudomotor and cardiovagal testing (QSART) for autonomic fibers. Unless an underlying disease is identified, treatment is usually symptomatic and directed towards alleviation of neuropathic pain.
小纤维神经病变（SFN）是一种选择性累及小直径有髓和无髓神经纤维的神经病变。在过去几年中，对这种疾病的关注显著增加。它通常是特发性的，典型表现为外周疼痛和/或自主神经功能障碍症状。诊断基于临床特征、正常的神经传导研究（NCS）以及小神经纤维的异常专项检查。其中，这些检查包括表皮神经纤维密度评估、感觉纤维温度感觉测试以及自主神经纤维的汗腺运动和心血管迷走神经测试（定量汗液轴突反射试验）。除非确定潜在疾病，治疗通常是对症的，旨在缓解神经性疼痛。
