Calí Patrizia, Naerum Lars, Mukhija Seema, Hjelmencrantz Anders
Combio A/S, Vesterbrogade 188, DK-1800 Frederiksberg C, Denmark.
Bioorg Med Chem Lett. 2004 Dec 20;14(24):5997-6000. doi: 10.1016/j.bmcl.2004.09.087.
A series of isoxazole-3-hydroxamic acid derivatives has been identified as a new class of small, nonpeptidic inhibitors of peptide deformylase (PDF). The synthesis, enzyme inhibition and preliminary investigation of the binding mode of this potential antibacterial compounds are reported.
一系列异恶唑-3-异羟肟酸衍生物已被鉴定为一类新型的小分子、非肽类肽脱甲酰基酶(PDF)抑制剂。本文报道了这类潜在抗菌化合物的合成、酶抑制作用以及结合模式的初步研究。