具有非肽骨架的肽脱甲酰酶抑制剂：合成与构效关系。
Peptide deformylase inhibitors with non-peptide scaffold: synthesis and structure-activity relationships.
机构信息
Promeditech Ltd, College of Pharmacy, Seoul National University, Seoul 151-742, Republic of Korea.
出版信息
Bioorg Med Chem Lett. 2011 Jan 1;21(1):133-6. doi: 10.1016/j.bmcl.2010.11.056. Epub 2010 Nov 16.
PMID:21146987
Abstract
Peptide deformylase (PDF), which removes the formyl group at the N-terminal methionine residue of nascent protein, has been recognized as a potent target for antibacterial therapy. We report herein the synthesis and structure-activity relationship studies of non-peptide PDF inhibitors.
摘要
肽脱甲酰基酶（PDF）能够去除新生蛋白质 N 端甲硫氨酸残基上的甲酰基，已被认为是一种有潜力的抗菌治疗靶点。本文报道了非肽 PDF 抑制剂的合成及构效关系研究。
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