基于琥珀酸 2-丁酯的异恶唑环羟肟酸酯衍生物的合成及初步抗菌评价。
Synthesis and preliminary antibacterial evaluation of 2-butyl succinate-based hydroxamate derivatives containing isoxazole rings.
机构信息
School of Chemistry and Chemical Engineering, Shandong University, Jinan, Shandong, China.
出版信息
Arch Pharm Res. 2010 Jun;33(6):831-42. doi: 10.1007/s12272-010-0605-7. Epub 2010 Jul 6.
PMID:20607487
Abstract
Two series of novel 2-butyl succinate-based Hydroxamate derivatives containing isoxazole rings were synthesized, characterized and evaluated for antibacterial activity. The synthesized compounds were found to exhibit weak to moderate inhibitory activity against Staphytlococcus aureu and Klebsiellar pneumonia in vitro. All the compounds synthesized were found to be more effective against Klebsiellar pneumonia compared to Staphytlococcus aureu.
摘要
合成并表征了两个系列新型的 2-丁基琥珀酸酯基异恶唑啉酮类羟肟酸衍生物，并评估了它们的抗菌活性。结果表明，所合成的化合物对金黄色葡萄球菌和肺炎克雷伯氏菌具有较弱至中等的抑制活性。与金黄色葡萄球菌相比，所有合成的化合物对肺炎克雷伯氏菌的抑制作用更强。
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