康尼酸（庚酮酸）对不同来源的3-磷酸甘油醛脱氢酶的抑制作用。
Koningic acid (heptelidic acid) inhibition of glyceraldehyde-3-phosphate dehydrogenases from various sources.
作者信息
Kato M, Sakai K, Endo A
机构信息
Department of Applied Biological Science, Tokyo Noko University, Japan.
出版信息
Biochim Biophys Acta. 1992 Mar 27;1120(1):113-6. doi: 10.1016/0167-4838(92)90431-c.
PMID:1554737
Abstract
Koningic acid is a potent inhibitor of glyceraldehyde-3-phosphate dehydrogenase (GAPDH), which binds to the cysteine residue at the active site. We have determined sensitivity of GAPDHs in comparison with their amino acid sequences. It was found that koningic acid sensitivity of GAPDHs is highly dependent on the sequences of the S-loop domain of the enzyme.
摘要
koningic酸是3-磷酸甘油醛脱氢酶（GAPDH）的一种强效抑制剂，它与活性位点的半胱氨酸残基结合。我们已经根据其氨基酸序列确定了GAPDHs的敏感性。结果发现，GAPDHs对koningic酸的敏感性高度依赖于该酶S环结构域的序列。
Zotero 插件