Endo A, Hasumi K, Sakai K, Kanbe T
J Antibiot (Tokyo). 1985 Jul;38(7):920-5. doi: 10.7164/antibiotics.38.920.
A sesquiterpene named koningic acid has been isolated from a strain of Trichoderma koningii as a potent inhibitor of ATP generation in the glycolytic pathway. From experiments with both cultured mouse carcinoma FM3A cells and isolated enzymes, it was shown that koningic acid is a specific inhibitor of glyceraldehyde 3-phosphate dehydrogenase that catalyzes the conversion of glyceraldehyde 3-phosphate to 3-phosphoglycerate.
从一株康氏木霉中分离出一种名为 koningic 酸的倍半萜烯，它是糖酵解途径中 ATP 生成的强效抑制剂。通过对培养的小鼠癌 FM3A 细胞和分离酶的实验表明，koningic 酸是甘油醛 3-磷酸脱氢酶的特异性抑制剂，该酶催化甘油醛 3-磷酸转化为 3-磷酸甘油酸。
