Osweiler G D, Ross P F, Wilson T M, Nelson P E, Witte S T, Carson T L, Rice L G, Nelson H A
Veterinary Diagnostic Laboratory, College of Veterinary Medicine, Iowa State University, Ames 50011.
J Vet Diagn Invest. 1992 Jan;4(1):53-9. doi: 10.1177/104063879200400112.
In 1989, corn screenings were associated with acute interstitial pulmonary edema, hydrothorax, and death in swine. Attack rate was 5-50%, case fatality rate was 50-90%, and clinical course was 1-2 days. Screenings from farms with pigs affected with pulmonary edema contained 20-330 micrograms fumonisin B1 per gram. Screenings containing 92 micrograms fumonisin B1 per gram fed to weanling pigs caused pulmonary edema and death. Sterilized corn inoculated with Fusarium moniliforme and diluted 1:1 with clean corn contained fumonisin B1 (17 micrograms/g) and caused acute pulmonary edema when fed for 5 days. Survivors developed subacute hepatotoxicosis with individual hepatocellular necrosis, hepatomegalocytosis, and increased numbers of mitotic figures. Similar liver lesions occurred in pigs given fumonisin B1 intravenously at 0.8 mg/kg body weight for 14 days.
1989年，玉米筛选物与猪的急性间质性肺水肿、胸腔积液及死亡有关。发病率为5% - 50%，病死率为50% - 90%，病程为1 - 2天。受肺水肿影响的猪场的筛选物每克含20 - 330微克伏马菌素B1。每克含92微克伏马菌素B1的筛选物喂给断奶仔猪会导致肺水肿和死亡。用串珠镰刀菌接种并与干净玉米按1:1稀释的灭菌玉米含有伏马菌素B1（17微克/克），喂食5天会引起急性肺水肿。存活猪出现亚急性肝中毒，有个别肝细胞坏死、肝巨细胞症及有丝分裂象数量增加。给猪静脉注射0.8毫克/千克体重的伏马菌素B1，持续14天，也会出现类似的肝脏病变。
