Doner Fehmi, Sari Ibrahim, Yariktas Murat, Dogru Harun
Department of Otorhinolaryngology, Suleyman Demirel University School of Medicin,e, Isparta, Turkey.
Am J Otolaryngol. 2004 Nov-Dec;25(6):407-10. doi: 10.1016/j.amjoto.2004.04.014.
The aim of this study was to compare intracellular adhesion molecule-1 (ICAM-1) expression in nasal polyp cases who were administered topical corticosteroid and in middle turbinates.
Twenty-four patients with nasal polyps were included in the study group. These patients were treated with 100 microg budesonide in each nostril twice daily for 2 months before the surgery. Twenty-one nonatopic patients with concha bullosa were included in the control group. The specimens were taken from patients undergoing endoscopic surgery.
In polyps, significantly higher mean ICAM-1 intensity scores were found by comparison with the control turbinates.
Corticosteroid treatment in patients with nasal polyps does not diminish ICAM-1 to that of turbinate tissue. The initiating events in the formation of nasal polyps still occur in these patients despite treatment with the topical nasal steroid.
本研究旨在比较局部使用皮质类固醇的鼻息肉患者与中鼻甲中细胞间黏附分子-1（ICAM-1）的表达情况。
研究组纳入24例鼻息肉患者。这些患者在手术前2个月每天两次在每个鼻孔使用100微克布地奈德治疗。对照组纳入21例患有泡状鼻甲的非特应性患者。标本取自接受内镜手术的患者。
与对照鼻甲相比，息肉中ICAM-1平均强度评分显著更高。
鼻息肉患者的皮质类固醇治疗并未使ICAM-1降低至鼻甲组织的水平。尽管使用了局部鼻用类固醇进行治疗，但这些患者鼻息肉形成的起始事件仍然会发生。
