Raijmakers Maarten T M, van Tits Berry J H, Hak-Lemmers Heidi L M, Roes Eva Maria, Steegers Eric A P, Peters Wilbert H M
Department of Gastroenterology, University Medical Center, Nijmegen, The Netherlands.
Acta Obstet Gynecol Scand. 2004 Dec;83(12):1173-7. doi: 10.1111/j.0001-6349.2004.00539.x.
Markers of lipid peroxidation are commonly used to assess oxidative stress in preeclampsia. The aim of this study was to assess the concentration of oxidized low density lipoprotein (oxLDL), a novel marker for lipid peroxidation, and that of the thiobarbituric acid reactive substances (TBARS) in the pathogenesis of severe preeclampsia and to investigate the influence of gestational age on these parameters.
Plasma levels of oxLDL and TBARS were assayed in women with severe preeclampsia (n = 40), normotensive pregnant controls matched for gestational age (n = 24) and normotensive pregnant controls at full term (n = 16).
Women with preeclampsia showed lower oxLDL levels (mean +/- SE) than matched controls (181 +/- 12 vs. 219 +/- 14; p = 0.027), whereas no differences were found for the TBARS concentration (3.8 +/- 0.6 vs. 3.7 +/- 0.4). When women with preeclampsia were compared to control women at full term, TBARS were elevated (3.8 +/- 0.6 vs. 1.5 +/- 0.2; p = 0.01). However, in women with normotensive pregnancy TBARS were also lower in full-term control pregnancy compared to early third-trimester values (p < 0.0001).
Plasma TBARS decreased during the third trimester of pregnancy, underlining the importance of matching for gestational age when studying markers of lipid peroxidation in pregnant women. Women with preeclampsia had lower plasma levels of oxLDL compared to gestational age-matched controls, indicating that oxLDL could be a marker for preeclampsia.
脂质过氧化标志物常用于评估子痫前期的氧化应激。本研究旨在评估氧化型低密度脂蛋白（oxLDL，一种新型脂质过氧化标志物）的浓度以及硫代巴比妥酸反应性物质（TBARS）在重度子痫前期发病机制中的浓度，并研究孕周对这些参数的影响。
检测重度子痫前期患者（n = 40）、孕周匹配的血压正常孕妇对照组（n = 24）和足月血压正常孕妇对照组（n = 16）血浆中oxLDL和TBARS的水平。
子痫前期患者的oxLDL水平（均值±标准误）低于匹配的对照组（181±12 vs. 219±14；p = 0.027），而TBARS浓度无差异（3.8±0.6 vs. 3.7±0.4）。将子痫前期患者与足月对照组女性相比，TBARS升高（3.8±0.6 vs. 1.5±0.2；p = 0.01）。然而，在血压正常的孕妇中，足月对照组孕妇的TBARS也低于孕晚期早期的值（p < 0.0001）。
妊娠晚期血浆TBARS降低，强调在研究孕妇脂质过氧化标志物时匹配孕周的重要性。与孕周匹配的对照组相比，子痫前期患者血浆oxLDL水平较低，表明oxLDL可能是子痫前期的一个标志物。
