Gratacós Eduard, Casals Elena, Gómez Olga, Llurba Elisa, Mercader Imma, Cararach Vicenç, Cabero Lluís
Fetal Medicine Unit, Department of Obstetrics and Gynaecology, Hospital Vall d'Hebron, Universitat Autònoma de Barcelona, Spain.
BJOG. 2003 Apr;110(4):400-4.
To evaluate the susceptibility to oxidation of low density lipoprotein (LDL) in women with a history of pre-eclampsia.
A case-control study.
The departments of obstetrics and gynaecology at two university teaching hospitals.
Women delivering one to three years before enrollment, 35 who were diagnosed with severe pre-eclampsia and 35 controls matched for age, body mass index (BMI), smoking and parity.
Plasma samples were analysed for total cholesterol, high density lipoprotein (HDL) cholesterol, LDL cholesterol, triglycerides and lipoprotein A. The in vitro susceptibility to oxidation of LDL was measured and expressed in minutes (lag time). Results are expressed as mean and standard deviation.
Serum lipid profile and in vitro susceptibility to oxidation of LDL.
Mean LDL cholesterol (116 [37] vs 98 [20] mg/dL, P < 0.05) and trygliceride (112 [56] vs 78 [38] mg/dL, P < 0.05) levels were significantly higher in the groups of women who had pre-eclampsia compared with controls. The rest of the measured lipid parameters were similar between the two study groups. The susceptibility to oxidation of LDL was also significantly higher in the pre-eclampsia group (lag time: 37.9 [8.4] vs 44.8 [9.1] minutes, P < 0.01).
Women with a history of pre-eclampsia have significant differences in lipid parameters and an increased susceptibility to lipoprotein oxidation when compared with women who had a normal pregnancy one to three years after delivery.
评估有子痫前期病史女性的低密度脂蛋白（LDL）氧化易感性。
病例对照研究。
两家大学教学医院的妇产科。
入组前1至3年分娩的女性，35例被诊断为重度子痫前期患者及35例年龄、体重指数（BMI）、吸烟情况和产次相匹配的对照者。
分析血浆样本中的总胆固醇、高密度脂蛋白（HDL）胆固醇、低密度脂蛋白胆固醇、甘油三酯和脂蛋白A。测量LDL的体外氧化易感性并以分钟（延迟时间）表示。结果以均值和标准差表示。
血清脂质谱和LDL的体外氧化易感性。
子痫前期女性组的平均低密度脂蛋白胆固醇水平（116[37]对98[20]mg/dL，P<0.05）和甘油三酯水平（112[56]对78[38]mg/dL，P<0.05）显著高于对照组。两个研究组之间其余测量的脂质参数相似。子痫前期组LDL的氧化易感性也显著更高（延迟时间：37.9[8.4]对44.8[9.1]分钟，P<0.01）。
与分娩后1至3年有正常妊娠的女性相比，有子痫前期病史的女性在脂质参数方面存在显著差异，且脂蛋白氧化易感性增加。
