前列腺癌早期检测指南的系统制定：德国在证据空白方面的做法
Systematic development of a guideline for early detection of prostate cancer: the German way in the evidence gap.
作者信息
Luboldt H-J, Fornara P, Weissbach L, Wirth M, Lorenz W, Rübben H
机构信息
Department of Urology, University of Duisburg-Essen, Hufelandstr. 55, Essen, Germany.
出版信息
Eur Urol. 2004 Dec;46(6):725-30. doi: 10.1016/j.eururo.2004.07.026.
OBJECTIVE
To develop an evidence-based guideline, helping physcians make prudent decisions about diagnostic care for men wishing to undergo examination for early detection of prostate cancer.
METHODS
A guideline development group, comprised of twenty healthcare professionals, including urologists, clinical chemists, pathologists, geriatricians, epidemiologists, technicians and a member of a patient self-help group, systematically gathered, evaluated, and discussed the most recent research available on early detection of prostate cancer. Nominal group technique (NGT) was employed to facilitate the decision-making process.
RESULTS
The NGT was sufficient to find a consensus among different medical disciplines in a timely fashion. A standardized guideline, containing a short version for physicians and a standardized patient information booklet, for nation-wide use was developed.
CONCLUSIONS
Population-based screening is not favoured, instead information should be given to men in their 50-70s, to enable shared decision-making between physician and patient for or against PSA-based early detection of prostate cancer.
目的
制定一项循证指南，帮助医生就希望接受前列腺癌早期检测检查的男性的诊断护理做出审慎决策。
方法
一个由二十名医疗保健专业人员组成的指南制定小组，包括泌尿科医生、临床化学家、病理学家、老年病学家、流行病学家、技术人员和一名患者自助组织成员，系统地收集、评估并讨论了有关前列腺癌早期检测的最新研究。采用名义群体技术（NGT）来促进决策过程。
结果
NGT足以及时在不同医学学科之间达成共识。制定了一项标准化指南，包括供医生使用的简短版本和标准化患者信息手册，供全国使用。
结论
不支持基于人群的筛查，相反，应向50至70岁的男性提供信息，以便医生和患者就是否基于前列腺特异性抗原（PSA）进行前列腺癌早期检测进行共同决策。
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