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主动脉缩窄修复术后年轻高血压患者的运动能力及右臂与腿部收缩压差异

Exercise capacity in young adults with hypertension and systolic blood pressure difference between right arm and leg after repair of coarctation of the aorta.

作者信息

Instebø Arne, Norgård Gunnar, Helgheim Vegard, Røksund Ola Drange, Segadal Leidulf, Greve Gottfried

机构信息

Department of Paediatrics, Haukeland University Hospital, 5020 Bergen, Norway.

出版信息

Eur J Appl Physiol. 2004 Oct;93(1-2):116-23. doi: 10.1007/s00421-004-1180-8. Epub 2004 Jul 28.

Abstract

Coarctation of the aorta represents 5-7% of congenital heart defects. Symptoms and prognosis depend on the degree of stenosis, age at surgery, surgical method and the presence of other heart defects. Postoperative complications are hypertension, restenosis and an abnormal blood pressure response during exercise. This study includes 41 patients, 15-40 years old, operated in the period 1975-1996. All were exercised on a treadmill until maximal oxygen consumption was achieved. Blood pressure was measured in the right arm and leg before and immediately after exercise, and in the right arm during exercise. Oxygen consumption was monitored and we defined an aerobic phase, an isocapnic buffering phase and a hypocapnic hyperventilation phase. The resting systolic blood pressure correlates with the resting systolic blood pressure difference between right arm and leg. A resting systolic blood pressure difference between the right arm and leg of 0.13 kPa (1 mmHg) to 2.67 kPa (20 mmHg) corresponds with a slight increase in resting systolic blood pressure. This rise in blood pressure increases the aerobic phase of the exercise test, helping the patients to achieve higher maximal oxygen consumption. A resting systolic blood pressure difference of more than 2.67 kPa (20 mmHg) corresponds with severe hypertension and causes reduction in the aerobic phase and maximal oxygen consumption. Resting systolic blood pressure and resting systolic blood pressure difference between the right arm and leg are not indicators for blood pressure response during exercise. Exercise testing is important to reveal exercise-induced hypertension and to monitor changes in transition from aerobic to anaerobic exercise and limitation to exercise capacity.

摘要

主动脉缩窄占先天性心脏缺陷的5%-7%。症状和预后取决于狭窄程度、手术时的年龄、手术方法以及是否存在其他心脏缺陷。术后并发症包括高血压、再狭窄以及运动期间血压反应异常。本研究纳入了41例年龄在15至40岁之间、于1975年至1996年期间接受手术的患者。所有患者均在跑步机上进行运动,直至达到最大耗氧量。在运动前、运动刚结束后测量右臂和腿部的血压,并在运动期间测量右臂血压。监测耗氧量,并定义了有氧阶段、等碳酸缓冲阶段和低碳酸过度通气阶段。静息收缩压与右臂和腿部静息收缩压差值相关。右臂和腿部静息收缩压差值在0.13 kPa(1 mmHg)至2.67 kPa(20 mmHg)之间,对应静息收缩压略有升高。血压的这种升高增加了运动试验的有氧阶段,有助于患者达到更高的最大耗氧量。静息收缩压差值超过2.67 kPa(20 mmHg)对应严重高血压,并导致有氧阶段和最大耗氧量降低。静息收缩压以及右臂和腿部静息收缩压差值并非运动期间血压反应的指标。运动测试对于揭示运动诱发的高血压以及监测从有氧运动向无氧运动转变过程中的变化和运动能力受限情况很重要。

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