Moschiano F, D'Amico D, Ciusani E, Erba N, Rigamonti A, Schieroni F, Bussone G
L. Mandic Hospital, Via L. Mandic 1, Merate (LC), Italy.
Neurol Sci. 2004 Oct;25 Suppl 3:S126-8. doi: 10.1007/s10072-004-0269-5.
Migraine, particularly migraine with aura, is a risk factor for ischaemic stroke. The mechanisms underlying this association are obscure. One hypothesis is that shared risk factors may be the cause of this association. Over the last decade, studies have suggested an association between migraine and genetic abnormalities in coagulation factors which play an important role in stroke pathogenesis. Although the results of studies on various prothrombotic conditions are conflicting, findings suggest a higher frequency of some genetic abnormalities in migraine with aura patients. Thus, persistent hypercoagulability may explain the tendency for these patients to develop thromboembolic cerebrovascular events, especially when they are exposed to additional procoagulant stresses. Further studies on larger samples are required to test this hypothesis.
偏头痛，尤其是伴有先兆的偏头痛，是缺血性中风的一个危险因素。这种关联背后的机制尚不清楚。一种假说认为，共同的危险因素可能是这种关联的原因。在过去十年中，研究表明偏头痛与凝血因子的基因异常之间存在关联，而凝血因子在中风发病机制中起重要作用。尽管关于各种血栓前状态的研究结果相互矛盾，但研究结果表明，伴有先兆偏头痛患者中某些基因异常的发生率更高。因此，持续的高凝状态可能解释了这些患者发生血栓栓塞性脑血管事件的倾向，尤其是当他们受到额外的促凝压力时。需要对更大样本进行进一步研究以验证这一假说。
