Patel H S, Peters M D, Smith C L
Department of Pharmacy Practice and Administration, College of Pharmacy, Rutgers, State University of New Jersey, Piscataway 08855.
Ann Pharmacother. 1992 Mar;26(3):350-3. doi: 10.1177/106002809202600309.
To review the data describing the use of fluconazole in the treatment of vulvovaginal candidiasis (VVC).
A MEDLINE search of the English-language literature and a bibliographic review of pertinent articles examining the use of fluconazole in the treatment of VVC.
Relevant open and controlled studies reporting on the efficacy, associated adverse effects, or both of fluconazole for the treatment of VVC are reviewed. Appropriate conclusions and/or data are extracted from each article and described.
Studies comparing fluconazole with ketoconazole and topical antifungal agents such as clotrimazole and miconazole have shown fluconazole to be equally efficacious with minimal adverse effects. Most of these trials used single-dose fluconazole, which would theoretically lead to a high degree of medication compliance. Fluconazole also has shown promise at diminishing VVC relapse or recurrence, possibly because of more complete vaginal and rectal eradication of Candida species. Pharmacoeconomically, single-dose fluconazole therapy is cost-effective; however, the recent approval of miconazole and clotrimazole by the Food and Drug Administration for over-the-counter use may limit this potential advantage.
Until additional data are available, fluconazole may be considered a treatment alternative for women with VVC who experience frequent relapses or recurrences, or for those who are noncompliant with standard therapy.
回顾描述氟康唑用于治疗外阴阴道念珠菌病（VVC）的数据。
对英文文献进行MEDLINE检索，并对有关氟康唑治疗VVC的相关文章进行文献综述。
对报告氟康唑治疗VVC的疗效、相关不良反应或两者的相关开放和对照研究进行综述。从每篇文章中提取适当的结论和/或数据并进行描述。
比较氟康唑与酮康唑以及克霉唑和咪康唑等局部抗真菌药的研究表明，氟康唑疗效相当且不良反应最小。这些试验大多使用单剂量氟康唑，理论上这会导致高度的用药依从性。氟康唑在减少VVC复发或再发方面也显示出前景，这可能是因为其能更彻底地清除阴道和直肠中的念珠菌。从药物经济学角度看，单剂量氟康唑治疗具有成本效益；然而，最近美国食品药品监督管理局批准咪康唑和克霉唑非处方使用可能会限制这一潜在优势。
在有更多数据之前，对于频繁复发或再发的VVC女性患者，或不依从标准治疗的患者，可考虑将氟康唑作为一种治疗选择。
