Iwase Hiroaki, Indo Toshihiko, Shimada Masaaki, Tsuzuki Tomoyuki, Nakarai Keiko, Kaida Syogo, Doi Reiko, Okeya Masayuki, Kato Eriko
Department of Gastroenterology, Nagoya National Hospital, 4-1-1 Sannomaru, Naka-ku, Nagoya 460-0001, Japan.
Int J Clin Oncol. 2004 Oct;9(5):398-402. doi: 10.1007/s10147-004-0412-6.
A 51-year-old man was hospitalized for evaluation of dysphagia and bloody stool. Gastrointestinal endoscopy showed esophageal cancer invading the gastric fundus. A metastatic lesion was demonstrated in the sigmoid colon. The patient agreed to have concurrent chemoradiotherapy for the primary lesion, followed by additional chemotherapy. The first course included 30 Gy of radiotherapy given over 3 weeks, together with daily oral administration of S-1 (80 mg/m2 per day) for 2 weeks, and a 24-h infusion of cisplatin (70 mg/m2) on day 8. After a second course of chemoradiotherapy, four additional courses of chemotherapy with S-1 and cisplatin were administered, at 4-week intervals. After the additional chemotherapy, gastroscopy and colonoscopy showed disappearance of both the primary and the metastatic lesions. One year after his initial hospitalization, no recurrence of either the primary or the metastatic tumor lesions is evident.
一名51岁男性因吞咽困难和便血入院评估。胃肠内镜检查显示食管癌侵犯胃底。乙状结肠发现转移灶。患者同意对原发灶进行同步放化疗，随后追加化疗。第一个疗程包括在3周内给予30 Gy放疗，同时连续2周每日口服S-1（80 mg/m²/天），并在第8天24小时输注顺铂（70 mg/m²）。在第二个放化疗疗程后，以4周的间隔追加了四个疗程的S-1和顺铂化疗。追加化疗后，胃镜和结肠镜检查显示原发灶和转移灶均消失。首次住院一年后，原发肿瘤和转移肿瘤病灶均未复发。
