Shin Seungwon, Kim Ji-Hyun
College of Pharmacy, Duksung Women's University, Seoul, Korea.
Planta Med. 2004 Nov;70(11):1090-2. doi: 10.1055/s-2004-832654.
The antifungal activities of essential oils from Thymus quinquecostatus and T. magnus, which are species native to Korea, were evaluated against seven common pathogenic fungi. Additionally, the effects of the oils together with ketoconazole were tested by the checkerboard titer test. Both of the two Thymus oils showed significant inhibition of the tested fungi, with minimal inhibitor concentrations (MICs) and minimal fungicidal concentrations (MFCs) in the range of 0.04-0.39 mg/mL and 0.19-0.78 mg/mL, respectively. The two Thymus oils, and thymol as well, exhibited synergism with ketoconazole against Trichophyton rubrum, which showed the highest susceptibility to these oils.
对原产于韩国的地椒和大百里香精油针对七种常见致病真菌的抗真菌活性进行了评估。此外，通过棋盘滴定法测试了这些精油与酮康唑联用的效果。两种百里香精油均对受试真菌表现出显著抑制作用，其最低抑菌浓度（MIC）和最低杀菌浓度（MFC）分别在0.04 - 0.39毫克/毫升和0.19 - 0.78毫克/毫升范围内。这两种百里香精油以及百里香酚与酮康唑联用对红色毛癣菌表现出协同作用，红色毛癣菌对这些精油的敏感性最高。
