做出正确选择——发育过程中的长程染色体相互作用

Making the right choice--long-range chromosomal interactions in development.

作者信息

Broach James R

机构信息

Department of Molecular Biology, Princeton University, Princeton, NJ 08558, USA.

出版信息

Cell. 2004 Nov 24;119(5):583-6. doi: 10.1016/j.cell.2004.11.029.

DOI:10.1016/j.cell.2004.11.029

PMID:15550239

Abstract

Schizosaccharomyces pombe has the remarkable potential to switch mating type as often as every generation, through selective interaction of an expressor locus with either of two transcriptionally silent donor loci. Recent results demonstrate that selection of the appropriate donor locus likely occurs through mating-type and heterochromatin-dependent spreading of a protein complex that marks the correct donor locus.

摘要

粟酒裂殖酵母具有非凡的潜力，能够每隔一代就转换交配型，这是通过一个表达位点与两个转录沉默的供体位点之一进行选择性相互作用来实现的。最近的研究结果表明，合适的供体位点的选择可能是通过一种蛋白质复合物的交配型和异染色质依赖性扩散来实现的，该复合物标记正确的供体位点。