Wittkugel Oliver, Koops Andreas, Habermann Christian R, Weiss Florian, Adam Gerhard, Krupski Gerrit
Department of Diagnostic and Interventional Radiology, University Hospital Hamburg-Eppendorf, University of Hamburg, Germany.
Invest Radiol. 2004 Dec;39(12):717-22. doi: 10.1097/00004424-200412000-00002.
We sought to test the bile resistance of transjugular intrahepatic portosystemic shunt (TIPS) stents with 3 different coatings.
Three stents with different coating materials (monolayer polyethylene terephthalate [PETP], monolayer polytetrafluoroethylene [PTFE], and double layer [PTFE]) were tested in a flow model. After testing the sealing of the system with isotonic saline solution, fresh human bile was circulated. Constant pressure was 50 cm H2O. Bile resistance of the stent membranes was analyzed.
Two of the 3 stents proved completely resistant to water. Only the PETP stent was resistant to bile. The PTFE-coated stents were not bile resistant.
The bile resistance of coated TIPS stents and, thus, the dependency of TIPS shunt patency is called into question. The stent with the reported superior patency rates does not show experimental bile resistance.
我们试图测试具有3种不同涂层的经颈静脉肝内门体分流术（TIPS）支架的抗胆汁性。
在流动模型中测试三种具有不同涂层材料的支架（单层聚对苯二甲酸乙二酯[PETP]、单层聚四氟乙烯[PTFE]和双层[PTFE]）。在用等渗盐溶液测试系统的密封性后，使新鲜人胆汁循环。恒定压力为50 cm H2O。分析支架膜的抗胆汁性。
3个支架中有2个被证明完全防水。只有PETP支架抗胆汁。涂有PTFE的支架不抗胆汁。
涂层TIPS支架的抗胆汁性以及TIPS分流通畅性的依赖性受到质疑。报道中具有较高通畅率的支架并未显示出实验性抗胆汁性。
