乳腺磁共振动态成像对乳头溢液性导管内病变的诊断价值评估
Evaluation of dynamic studies of MR mammography for the diagnosis of intraductal lesions with nipple discharge.
作者信息
Ishikawa Takashi, Momiyama Nobuyoshi, Hamaguchi Yohei, Takeuchi Maho, Iwasawa Tae, Yoshida Tetsuo, Shimada Hiroshi
机构信息
Second Department of Surgery, Yokohama City University, 3-9 Fukuura, Kanazawa-ku, Yokohama, Japan.
出版信息
Breast Cancer. 2004;11(3):288-94. doi: 10.1007/BF02984551.
OBJECTIVES
We assessed the utility of dynamic magnetic resonance imaging (MRI) in differentiating benign from malignant lesions of the breast and then applied MRI to diagnose intraductal breast tumors with nipple discharge.
METHODS
Gadolinium (Gd)-enhanced MR mammography was performed on 74 patients with breast tumors and 8 patients with nipple discharge.
RESULTS
The steepest slopes of the contrast medium uptake (S slope) s from time-intensity curves were significantly different between malignant and benign lesions. At S slope threshold of 0.95% /second, malignancy was predicted with a sensitivity and specificity of 75% . Six of 8 cases with nipple discharge were successfully identified by MR ductography by injecting Gd-DTPA into discharging ducts. Among them, 2 non-invasive ductal carcinomas were differentiated from benign lesions by the S slope value.
CONCLUSIONS
Dynamic MR mammography is an useful modality for differentiating breast lesions and has potential for evaluating intraductal lesions with nipple discharge.
目的
我们评估了动态磁共振成像（MRI）在鉴别乳腺良恶性病变中的效用，然后应用MRI诊断伴有乳头溢液的导管内乳腺肿瘤。
方法
对74例乳腺肿瘤患者和8例乳头溢液患者进行钆（Gd）增强乳腺磁共振成像检查。
结果
恶性和良性病变之间，对比剂摄取的最大斜率（S斜率）从时间-强度曲线来看有显著差异。在S斜率阈值为0.95%/秒时，预测恶性肿瘤的敏感度和特异度为75%。通过向溢液导管内注射Gd-DTPA，8例乳头溢液患者中有6例通过磁共振导管造影成功确诊。其中，2例非浸润性导管癌通过S斜率值与良性病变相鉴别。
结论
动态乳腺磁共振成像是鉴别乳腺病变的一种有用方法，并且在评估伴有乳头溢液的导管内病变方面具有潜力。
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