Fukuda Satoru, Kawaguchi Masahiko, Kakinohana Manabu, Matsumoto Mishiya
Department of Anesthesiology and Reanimatology, Faculty of Medical Science, University of Fukui.
Masui. 2004 Oct;53(10):1106-29.
The incidence of postoperative paralysis after thoracic and thoracoabdominal aortic operations has decreased, but is still high in comparison with other operations. The analysis of the mechanism involved in the ischemic tolerance of the spinal cord could contribute to the protection of the spinal cord from ischemia. The identification of the Adamkiewicz artery and the predictive factors for postoperative paralysis in the preoperative period, the use of motor evoked potential, several adjuncts to keep the spinal cord circulation, the stabilization of the hemodynamics with good oxygenation, and hypothermia contribute to the prevention of the spinal cord ischemia. The anesthetics appropriate for the monitoring of the motor-evoked potential are propofol and fentanyl with or without ketamine. Among the anesthetic drugs, narcotics might exacerbate the motor function after the spinal cord ischemia. The analgesic drugs which do not aggravate the spinal cord dysfunction would be expected. Good cooperation of surgeons and anesthesiologists greatly contributes to the finding of the spinal cord ischemia during this operation.
胸主动脉和胸腹主动脉手术后术后瘫痪的发生率有所下降,但与其他手术相比仍居高不下。对脊髓缺血耐受机制的分析有助于保护脊髓免受缺血损伤。术前识别Adamkiewicz动脉和术后瘫痪的预测因素、使用运动诱发电位、多种维持脊髓循环的辅助措施、维持良好氧合的血流动力学稳定以及低温,都有助于预防脊髓缺血。适用于运动诱发电位监测的麻醉药物是丙泊酚和芬太尼,可加用或不加用氯胺酮。在麻醉药物中,麻醉性镇痛药可能会加重脊髓缺血后的运动功能。人们期望使用不会加重脊髓功能障碍的镇痛药。外科医生和麻醉医生的良好配合对术中发现脊髓缺血有很大帮助。