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乳品之州的佝偻病

Rickets in the Dairy State.

作者信息

Mylott Brandt M, Kump Theresa, Bolton Marilyn L, Greenbaum Larry A

机构信息

Children's Hospital of Wisconsin, USA.

出版信息

WMJ. 2004;103(5):84-7.

Abstract

BACKGROUND

Nutritional vitamin D deficiency rickets occurs when children do not receive adequate vitamin D, which can be obtained from diet or manufactured in the skin when there is adequate sun exposure. A number of reports have described cases of vitamin D deficiency rickets in breastfed infants, but the public health significance of this problem in Wisconsin is unknown.

OBJECTIVES

Our objectives were to identify cases of vitamin D deficiency rickets in Wisconsin infants and to determine the percentage of these infants participating in the Wisconsin Women, Infant and Children (WIC) program.

METHODS

All cases of rickets due to nutritional vitamin D deficiency seen at Children's Hospital of Wisconsin or its associated outpatient clinics were identified by retrospective chart review. Data collected included date of birth, age at presentation, race, clinical presentation, diet history, history of vitamin supplementation, x-ray findings, and biochemical studies. The children with nutritional vitamin D deficiency rickets were cross-referenced with the Wisconsin WIC database.

RESULTS

Fifty-one definite cases of nutritional vitamin D deficiency rickets were identified. Skeletal deformities, failure to thrive, fractures, seizures, incidental lab finding, tetany, and refusal to walk were the most common reasons for identifying rickets. All of the children were breastfed and did not receive vitamin supplementation. The infants had a mean age of 13.6 months and 46 (90%) were African American. Thirty-seven out of 51 children (73%) were enrolled in the Wisconsin WIC program.

CONCLUSION

Vitamin D deficiency nutritional rickets is an important public health problem in Wisconsin. The Wisconsin WIC program may be an important site for intervention strategies.

摘要

背景

当儿童未获得足够的维生素D时,就会发生营养性维生素D缺乏性佝偻病,维生素D可从饮食中获取,或在有充足阳光照射时由皮肤合成。已有多篇报告描述了母乳喂养婴儿中维生素D缺乏性佝偻病的病例,但该问题在威斯康星州的公共卫生意义尚不清楚。

目的

我们的目的是确定威斯康星州婴儿维生素D缺乏性佝偻病的病例,并确定这些婴儿参加威斯康星州妇女、婴儿和儿童(WIC)项目的比例。

方法

通过回顾性病历审查,确定在威斯康星儿童医院或其相关门诊诊所所见的所有营养性维生素D缺乏所致佝偻病病例。收集的数据包括出生日期、就诊年龄、种族、临床表现、饮食史、维生素补充史、x光检查结果和生化研究。将营养性维生素D缺乏性佝偻病患儿与威斯康星州WIC数据库进行交叉对照。

结果

确定了51例明确的营养性维生素D缺乏性佝偻病病例。骨骼畸形、发育不良、骨折、癫痫发作、偶然实验室检查发现、手足搐搦和拒绝行走是诊断佝偻病最常见的原因。所有儿童均为母乳喂养,未接受维生素补充。这些婴儿的平均年龄为13.6个月,46名(90%)为非裔美国人。51名儿童中有37名(73%)参加了威斯康星州WIC项目。

结论

维生素D缺乏性营养性佝偻病是威斯康星州一个重要的公共卫生问题。威斯康星州WIC项目可能是实施干预策略的重要场所。

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