Sanders Sara R, Teachey Mary K, Ptock Arne, Kraemer Klaus, Hasselwander Oliver, Henriksen Erik J, Baumgard Lance H
Department of Animal Sciences, University of Arizona, Tucson, Arizona 85721, USA.
Lipids. 2004 Jun;39(6):537-43. doi: 10.1007/s11745-004-1260-0.
Growing female obese Zucker (fa/fa) rats were treated (via intragastric gavage) for 21 d with either a (i) vehicle [corn oil; 0.9 g/kg body weight (BW)], (ii) CLA mixture [50:50; trans-10, cis-12 and cis-9, trans-11 CLA], (iii) cis-9,trans-11 CLA, or (iv) trans- 10, cis-12 CLA (CLA treatments at 1.5 g CLA/kg BW). Compared with controls, average daily gain (g/d) was reduced 24 and 44% by the CLA mixture and trans-10, cis-12 CLA, respectively. There was no treatment effect on average whole-body (minus heart and liver) composition (dry matter basis): fat (70.2%), protein (21.0%), and ash (4.3%). Compared with animals treated with cis-9,trans-11 CLA, obese Zucker rats treated with trans-10, cis-12 and the CLA mixture had 7.8% more carcass water. Treatment had no effect on heart or liver weights or on heart or liver weights as a percentage of body weight, but compared with the other treatments trans-10, cis-12 CLA increased liver lipid content by 33%. Hepatic lipid ratios of 16:1/16:0 and 18:1/18:0 (a proxy for delta9-desaturase capability) were not affected by treatment (0.1 and 0.6, respectively). Similar to previous reports, CLA increased hepatic lipid content and altered both liver and carcass FA composition (i.e., reduced arachidonic acid content), but the ability of CLA to manipulate body composition in obese Zucker rats remains questionable.
对生长中的雌性肥胖Zucker（fa/fa）大鼠（通过灌胃法）进行为期21天的处理，处理方式如下：（i）赋形剂[玉米油；0.9克/千克体重（BW）]，（ii）共轭亚油酸混合物[50:50；反式-10，顺式-12和顺式-9，反式-11共轭亚油酸]，（iii）顺式-9，反式-11共轭亚油酸，或（iv）反式-10，顺式-12共轭亚油酸（共轭亚油酸处理剂量为1.5克共轭亚油酸/千克体重）。与对照组相比，共轭亚油酸混合物和反式-10，顺式-12共轭亚油酸分别使平均日增重（克/天）降低了24%和44%。对平均全身（心脏和肝脏除外）组成（干物质基础）没有处理效果：脂肪（70.2%）、蛋白质（21.0%）和灰分（4.3%）。与用顺式-9，反式-11共轭亚油酸处理的动物相比，用反式-10，顺式-12共轭亚油酸和共轭亚油酸混合物处理的肥胖Zucker大鼠胴体水分多7.8%。处理对心脏或肝脏重量或心脏或肝脏重量占体重的百分比没有影响，但与其他处理相比，反式-10，顺式-12共轭亚油酸使肝脏脂质含量增加了33%。肝脏中16:1/16:0和18:1/18:0的脂质比率（代表Δ9-去饱和酶能力）不受处理影响（分别为0.1和0.6）。与之前的报道相似，共轭亚油酸增加了肝脏脂质含量，并改变了肝脏和胴体的脂肪酸组成（即降低了花生四烯酸含量），但共轭亚油酸在肥胖Zucker大鼠中调节身体组成的能力仍值得怀疑。
