Kim Yoo, Kim Jonggun, Whang Kwang-Youn, Park Yeonhwa
Department of Food Science, University of Massachusetts, 102 Holdsworth Way, Amherst, MA, 01003, USA.
Division of Biotechnology, Korea University, Seoul, 136-713, Republic of Korea.
Lipids. 2016 Feb;51(2):159-78. doi: 10.1007/s11745-015-4115-8. Epub 2016 Jan 4.
Conjugated linoleic acid (CLA) has garnered special attention as a food bioactive compound that prevents and attenuates obesity. Although most studies on the effects of CLA on obesity have focused on the reduction of body fat, a number of studies have demonstrated that CLA also increases lean body mass and enhances physical performances. It has been suggested that these effects may be due in part to physiological changes in the skeletal muscle, such as changes in the muscle fiber type transformation, alteration of the intracellular signaling pathways in muscle metabolism, or energy metabolism. However, the mode of action for CLA in muscle metabolism is not completely understood. The purpose of this review is to summarize the current knowledge of the effects of CLA on skeletal muscle metabolism. Given that CLA not only reduces body fat, but also improves lean mass, there is great potential for the use of CLA to improve muscle metabolism, which would have a significant health impact.
共轭亚油酸（CLA）作为一种预防和减轻肥胖的食品生物活性化合物，已引起特别关注。尽管大多数关于CLA对肥胖影响的研究都集中在减少体脂上，但一些研究表明，CLA还能增加瘦体重并提高身体机能。有人认为，这些作用可能部分归因于骨骼肌的生理变化，如肌纤维类型转变的变化、肌肉代谢中细胞内信号通路的改变或能量代谢。然而，CLA在肌肉代谢中的作用方式尚未完全明确。本综述的目的是总结目前关于CLA对骨骼肌代谢影响的知识。鉴于CLA不仅能减少体脂，还能改善瘦体重，使用CLA改善肌肉代谢具有巨大潜力，这将对健康产生重大影响。
