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使用延迟纤维蛋白胶的生育率:大鼠输精管吻合术

Fertility rates with delayed fibrin glue: vasovasostomy in rats.

作者信息

Weiss J N, Mellinger B C

机构信息

Department of Urology, Long Island Jewish Medical Center, New Hyde Park, New York.

出版信息

Fertil Steril. 1992 Apr;57(4):908-11. doi: 10.1016/s0015-0282(16)54979-6.

Abstract

OBJECTIVE

To determine if fibrin glued vasovasostomy had comparable fertility rates to sutured vasovasostomy.

DESIGN

Twenty adult male Sprague-Dawley rats underwent bilateral vasectomy. Two weeks after vasectomy, 10 rats had a bilateral sutured vasal anastomosis consisting of four mucosal and four seromuscular sutures with 10-0 nylon. The second group of 10 rats underwent bilateral fibrin glue vasal anastomosis consisting of two transmural sutures with 10-0 nylon followed by application of fibrin glue. One month after vasectomy reversal, each male rat was mated with a female rat for a period of 2 weeks.

SETTING

Animal laboratory. PATIENTS PARTICIPANTS: Twenty male Sprague-Dawley rats.

INTERVENTIONS

Bilateral vasectomies in 20 male Sprague-Dawley rats. Two weeks after vasectomy, 10 rats had bilateral sutured vasal anastomosis, and 10 rats had bilateral glued vasal anastomosis.

MAIN OUTCOME MEASURES

Pregnancy after vasectomy reversal.

RESULTS

Ten of 10 rats in the sutured group produced offspring for a fertility rate of 100%. Eight of 10 rats in the fibrin glue group produced offspring for a fertility rate of 80%. There was no statistically significant difference in the pregnancy rates between the two groups at the 95% confidence interval.

CONCLUSION

Fibrin glue-delayed vasectomy reversal produces comparable fertility rates compared with conventional sutured vasectomy reversal in the rat.

摘要

目的

确定纤维蛋白胶黏合输精管吻合术的生育率是否与缝合输精管吻合术相当。

设计

20只成年雄性Sprague-Dawley大鼠接受双侧输精管切除术。输精管切除术后两周,10只大鼠进行双侧缝合输精管吻合术,用10-0尼龙线缝合4针黏膜和4针浆肌层。第二组10只大鼠进行双侧纤维蛋白胶输精管吻合术,先用10-0尼龙线缝合2针全层,然后应用纤维蛋白胶。输精管复通术后1个月,每只雄性大鼠与一只雌性大鼠交配2周。

地点

动物实验室。患者参与者:20只雄性Sprague-Dawley大鼠。

干预措施

20只雄性Sprague-Dawley大鼠进行双侧输精管切除术。输精管切除术后两周,10只大鼠进行双侧缝合输精管吻合术,10只大鼠进行双侧胶黏合输精管吻合术。

主要观察指标

输精管复通术后的妊娠情况。

结果

缝合组10只大鼠中有10只生育后代,生育率为100%。纤维蛋白胶组10只大鼠中有8只生育后代,生育率为80%。两组妊娠率在95%置信区间无统计学显著差异。

结论

在大鼠中,纤维蛋白胶延迟输精管复通术与传统缝合输精管复通术的生育率相当。

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