Vankemmel O, Rigot J M, Burnouf T, Mazeman E
Clinique Urologique, Centre Hospitalier Universitaire de Lille, France.
Eur Urol. 1997;31(2):182-6. doi: 10.1159/000474447.
We compare delayed vasectomy reversals performed in rats using fibrin glue combined with 3 transmural sutures or a conventional microsurgical technique. Forty Sprague-Dawley rats underwent bilateral vasectomy followed 2 weeks later by bilateral vasovasostomy using fibrin glue or a conventional microsurgical suture technique. Our protocol evaluated fertility rates after a 3-week mating period, sperm granuloma formation, histological changes at the anastomotic site, longitudinal tensile strength and mean testicular weight. The fibrin glue technique required significantly reduced operative time (p < 0.0005) and showed statistically lower tensile strength performance (p < 0.0005). All other parameters showed no statistical difference between the two techniques. Fibrin-glued vasovasostomy is efficient in a delayed protocol and deserves further clinical experience.
我们比较了在大鼠中使用纤维蛋白胶联合3条全层缝合线或传统显微外科技术进行的延迟输精管复通术。40只Sprague-Dawley大鼠接受双侧输精管结扎，2周后使用纤维蛋白胶或传统显微外科缝合技术进行双侧输精管吻合术。我们的方案评估了3周交配期后的生育率、精子肉芽肿形成、吻合部位的组织学变化、纵向拉伸强度和平均睾丸重量。纤维蛋白胶技术所需的手术时间显著缩短（p < 0.0005），并且拉伸强度表现统计学上较低（p < 0.0005）。其他所有参数在两种技术之间均无统计学差异。纤维蛋白胶黏合的输精管吻合术在延迟方案中是有效的，值得进一步的临床经验。
